Abstract: The sequence stratigraphy and sedimentary characteristics are dealt with for the block M in the Niger delta, Nigeria on the basis of high-resolution sequence stratigraphic theory, including the description of lithoclastics data from the whole wells, determination of responses of GR and AC to lithology, interpretation of lithologic sections of major wells, division and correlation of base-level cycles of varying orders, and construction of isochronous sequence stratigraphic framework. Nine long-term cycles are discriminated on the basis of cycle boundary and types. The types and spatio-temporal evolution of deltas in response to the sequences and systems tracts are discussed in the light of regional tectonics, sedimentary background and sediment supply. Finally the present paper gives a summary of cycle associations and stacking patterns of the sedimentary microfacies such as distributary channels, subaqueous distributary channels and sandbars aiming at providing the evidences in favour of the assessment of reservoir-seal associations and exploration targets.