Abstract: The Kelu-Chongmuda copper-gold ore district is sandwiched between Zhanang and Sangri in southern Xizang. The results of the geology, geochemistry, tectonic setting and metallogenic specialization of the Late Cretaceous granitoids in the Kelu-Chongmuda ore district led us to draw the following conclusions. (1) The Late Cretaceous granitoids consisting of diorite, quartz diorite and adamellite are assigned to the metaluminous highpotassium calc-alkaline I-type granites, and characterized by slightly differentiation and crystallization of plagioclase, enrichment of the elements Th and Sr, and depletion of the elements Ba and Nb. They are interpreted as the products from the partial melting of amphibolite in the orogenic zones. (2) The metallogenesis of the Late Cretaceous granitoids are mainly hosted in porphyroid biotite adamellite and biotite adamellite, locally in diorite and quartz diorite. The mineralization is chiefly manifested in the metallogenic potentiality of Cu, Pb-Zn and Mo.